"Mary’s award-winning transdermal patches are born out of a commitment to accurate dosing through an advanced delivery method. The 2”x2” squares simply adhere to any venous part of the skin for 8-12 hours of unsurpassed, systemic relief. -- • Discreet, convenient and reliable • Apply to any venous area of the skin for best results • Provides 8-12 hours of unsurpassed, systemic relief • High bioavailability • 15-30-minute uptake time"